Key result
Autopsy of a 70-year-old man with malignancy of unknown origin and renovascular hypertension revealed an aortic intimal sarcoma in the right renal artery.
Case Report (n=1)
No
In patients with malignancy of unknown origin presenting with bone metastases and acute or sub-acute renovascular hypertension, aortic intimal sarcoma in the renal artery should be considered as a potential etiology.
Aortic intimal sarcoma may explain renovascular hypertension in occult malignancy; single case leaves open need for diagnostic validation.
An autopsy of a 70-year-old man with multiple bone metastases from a malignancy of unknown origin (MUO) and renovascular hypertension revealed an aortic intimal sarcoma (AIS) in the right renal artery accompanied by atherosclerotic changes. AIS appeared as aggregated mutton fat-like translucent particles arising from the intima of the branching portion of the right renal artery and was composed of undifferentiated, fine spindle cells with thicket-like proliferation. AIS was confirmed by immunohistopathology, showing the loss of the lumen lined by CD31-positive endothelium and the expression of CD31, keratin, and vimentin in the viable part of the tumor. In patients with MUO presenting with both bone metastases and an acute or sub-acute onset of renovascular hypertension, AIS in the renal artery may be responsible.
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Ishii et al. (2016) conducted a case report in Renovascular hypertension and malignancy of unknown origin (n=1). Aortic intimal sarcoma was evaluated. Autopsy of a 70-year-old man with malignancy of unknown origin and renovascular hypertension revealed an aortic intimal sarcoma in the right renal artery.
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