Key result
A history of pregnancy-induced hypertension was associated with a significantly higher frequency of long-term endothelial dysfunction compared to women with no pregnancy complications (P=0.01).
Why the study?
Does a history of pregnancy-induced hypertension increase the risk of long-term endothelial dysfunction?
Cohort (n=60)
No
Does a history of pregnancy-induced hypertension increase the risk of long-term endothelial dysfunction?
A history of pregnancy-induced hypertension is associated with long-term endothelial dysfunction and adverse cardiovascular metabolic profiles.
May inform postpartum cardiovascular risk assessment; leaves open whether endothelial dysfunction predicts clinical events.
OBJECTIVE: To carry out long-term analysis of the presence of endothelial dysfunction after the development of pregnancy-induced hypertension (PIH). METHODS: In a retrospective cohort study, data were analyzed from 60 women who delivered at a tertiary maternity hospital in Fortaleza, Ceara, Brazil, between 1992 and 2002. Thirty women had a history of PIH and 30 had no history of complications. Anthropometric and laboratory data were collected, and endothelial function was evaluated by flow-mediated dilatation of the brachial artery. Continuous variables were analyzed via Student t test, and Mann-Whitney test was used to compare means. Clinical and metabolic measures were categorized according to cardiovascular risk by cutoff points determined by national consensus; χ2 and Fisher exact tests were used to compare the groups. Relative risk was calculated for variables that were statistically significant (P<0.05). RESULTS: Women with a history of PIH had higher body mass index (P=0.03), systolic blood pressure (P=0.03), low-density lipoprotein cholesterol (P=0.02), and fasting glucose (P=0.02) compared with women with no pregnancy complications. The frequency of endothelial dysfunction was 60% among all women, with a significant difference between the 2 groups (P=0.01). CONCLUSION: Women with a history of PIH were found to have a higher frequency of long-term endothelial dysfunction.
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Henriques et al. (2013) conducted a cohort in Pregnancy-induced hypertension (n=60). History of pregnancy-induced hypertension vs. No history of pregnancy complications was evaluated on Endothelial dysfunction evaluated by flow-mediated dilatation of the brachial artery (p=0.01). A history of pregnancy-induced hypertension was associated with a significantly higher frequency of long-term endothelial dysfunction compared to women with no pregnancy complications (P=0.01).
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