Key result
Intracoronary low-dose tissue plasminogen activator and systemic anticoagulation led to angiographic resolution of the thrombus and normalisation of left ventricular function in a neonate with MI.
Why the study?
Does intracoronary low-dose tissue plasminogen activator resolve thrombus and improve ventricular function in a neonate with acute myocardial infarction?
Case Report (n=1)
Does intracoronary low-dose tissue plasminogen activator resolve thrombus and improve ventricular function in a neonate with acute myocardial infarction?
Intracoronary low-dose tissue plasminogen activator may be an effective and safe treatment for neonatal myocardial infarction caused by coronary thrombosis.
Hypothesis-generating for intracoronary thrombolysis in neonatal MI; prospective studies needed before clinical adoption.
Neonatal myocardial infarction is a rare clinical entity that is associated with high mortality. Reported treatment strategies include supportive care, extracorporeal membrane oxygenation, thrombolytics, and surgical thrombectomy. Herein we report a neonate who developed an acute myocardial infarction owing to a thrombus in the proximal left coronary artery. At 24 hours of life, he was treated with local (intracoronary) thrombolytic therapy at a lower dose than previously reported, as well as with systemic anticoagulation. There was subsequent angiographic resolution of the thrombus and normalisation of left ventricular function.
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Hallbergson et al. (2014) conducted a case report in Neonatal myocardial infarction (n=1). Intracoronary low-dose tissue plasminogen activator and systemic anticoagulation was evaluated on Angiographic resolution of thrombus and normalisation of left ventricular function. Intracoronary low-dose tissue plasminogen activator and systemic anticoagulation led to angiographic resolution of the thrombus and normalisation of left ventricular function in a neonate with MI.
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