Key result
Quinacrine caused a fast, voltage-independent, and reversible dose-dependent reduction of the peak amplitude of high-threshold calcium channel currents in rat hippocampal neurones (Kd 30 +/- 5 microM).
Quinacrine selectively blocks high-threshold calcium channels in rat hippocampal neurons, highlighting its potential utility for pharmacological and structure-activity studies of calcium channels.
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Offers no immediate clinical translation; leaves open quinacrine as an in vitro probe for calcium channel studies.
Miroňov et al. (1992) studied this question. Quinacrine was evaluated on High-threshold calcium channel currents (IBa). Quinacrine caused a fast, voltage-independent, and reversible dose-dependent reduction of the peak amplitude of high-threshold calcium channel currents in rat hippocampal neurones (Kd 30 +/- 5 microM).
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