Key result
In COVID-19 ICU patients, full LVDD assessment was feasible in 74%, and LVDD incidence was 59% in hospital non-survivors compared to 22% in survivors (p=0.11).
Why the study?
LVDD is associated with poor outcomes in the ICU, but precise reporting in COVID-19 patients is lacking and assessment can be challenging.
Observational (n=35)
No
Echocardiographic assessment of left ventricular diastolic dysfunction is feasible in ICU COVID-19 patients, and specific parameters like E/e' ratio and s' wave are associated with hospital mortality.
LVDD parameters associated with mortality in ICU COVID-19; hypothesis-generating and requires prospective validation before clinical use.
Purpose: Left ventricular diastolic dysfunction (LVDD) is associated with poor outcomes in intensive care unit (ICU). Nonetheless, precise reporting of LVDD in COVID-19 patients is currently lacking and assessment could be challenging. Methods: We performed an echocardiography study in COVID-19 patients admitted to ICU with the aim to describe the feasibility of full or simplified LVDD assessment and its incidence. We also evaluated the association of LVDD or of single echocardiographic parameters with hospital mortality. Results: Between 06.10.2020 and 18.02.2021, full diastolic assessment was feasible in 74% (n=26/35) of patients receiving full echocardiogram study. LVDD incidence was 46% (n=12/26), whilst the assessment produced different results (incidence 81%, n=21/26). Nine patients were hospital-survivors (39%); incidence of LVDD (full assessment) was not different between survivors (n=2/9, 22%) and non-survivors (n=10/17, 59%; p=0.11). Also, the E/e’ ratio lateral was lower in survivors (7.4 [3.6] vs non-survivors 10.5 [6.3], p=0.03). We also found that s’ wave was higher in survivors (average, p=0.01). Conclusion: In a small single-center study, assessment of LVDD according to latest guidelines was feasible in three quarter of COVID-19 patients. Non-survivors showed a trend towards greater LVDD incidence; moreover, they had significantly worse s’ values (all) and higher E/e’ ratio (lateral).
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Via et al. (2022) conducted an observational in COVID-19 (n=35). Hospital mortality (non-survivors) vs. Hospital survivors was evaluated on Incidence of left ventricular diastolic dysfunction (LVDD) (p=0.11). In COVID-19 ICU patients, full LVDD assessment was feasible in 74%, and LVDD incidence was 59% in hospital non-survivors compared to 22% in survivors (p=0.11).
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