A three-component coupling of aldehydes, amines and an alkyne to generate propargylic amines in nearly quantitative yields, using a layered double hydroxide-supported gold (LDH-AuCl4) catalyst is described. Both aromatic and aliphatic aldehydes and amines are used for the reaction. No additional co-catalyst or activator is required.
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Kantam et al. (2005) studied this question.