Genomic analysis reveals that intergenic distance correlates with downstream gene expression in Escherichia coli, suggesting a mechanism to prevent ribosome interference.
It is shown that the distance between Escherichia coli genes oriented in the same direction on the chromosome is positively correlated to the expression level of the downstream gene. It is suggested that this could be a strategy to avoid interference between ribosomes translating two different genes.
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Adam Eyre‐Walker (1995) studied this question.
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