Experimental study demonstrates the synthesis of novel isoxazoline-bearing stellettin analogs, highlighting a modular pathway for complex triterpenoid scaffolds.
We designed and synthesized (±)-stellettin analogs featuring an isoxazoline ring. The key synthetic steps included the Meyer-Schuster rearrangement, an intramolecular nitrile oxide cycloaddition to create tetracyclic isoxazolines, and the incorporation of various side chains using the Wittig reaction.
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Wang et al. (2025) studied this question.
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