Key result
Higher severity of end-stage liver disease (MELD score) significantly correlated with increased left-atrial diameter (r=0.323; 95% CI 0.190-0.455; p<0.001) and systolic pulmonary artery pressure.
Why the study?
Does the severity of end-stage liver disease correlate with morphologic and functional heart changes in patients with cirrhosis?
Cross-Sectional (n=184)
Does the severity of end-stage liver disease correlate with morphologic and functional heart changes in patients with cirrhosis?
Effect estimate: r = 0.323 (95% CI 0.190-0.455)
p-value: p=<0.001
The severity of end-stage liver disease, as measured by the MELD score, is significantly correlated with adverse cardiac remodeling, including increased left-atrial diameter and systolic pulmonary artery pressure.
BACKGROUND: The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. MATERIAL AND METHODS: 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score. RESULTS: Left-atrial diameter (r = 0.323; IC 95% 0.190-0.455; p < 0.001), left-ventricular diastolic diameter (r = 0.177; IC 95% 0.033-0.320; p = 0.01) and systolic pulmonary artery pressure (r = 0.185; IC 95% 0.036-0.335; p = 0.02) significantly correlated with MELD score. Patients with MELD ≥ 16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores < 16 points. CONCLUSIONS: Changes in cardiac structure and function correlate with the severity of ESLD.
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Silvestre et al. (2013) conducted a cross-sectional in End-stage liver disease (cirrhosis) (n=184). Severity of end-stage liver disease (MELD score) vs. Lower MELD score (< 16) was evaluated on Correlation of MELD score with left-atrial diameter (r = 0.323, 95% CI 0.190-0.455, p=<0.001). Higher severity of end-stage liver disease (MELD score) significantly correlated with increased left-atrial diameter (r=0.323; 95% CI 0.190-0.455; p<0.001) and systolic pulmonary artery pressure.
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