Key result
Cirrhosis was associated with significant cardiac dysfunction, including increased cardiac output and decreased E/A ratio compared to controls, which worsened with increasing MELD scores.
Why the study?
Recent evidence has defined cirrhotic cardiomyopathy, but the relationship between cirrhosis severity and cardiac dysfunction required further evaluation.
Does the severity of cirrhosis (MELD score) correlate with echocardiographic and electrocardiographic markers of cardiac dysfunction?
Case-Control
Does the severity of cirrhosis (MELD score) correlate with echocardiographic and electrocardiographic markers of cardiac dysfunction?
Cirrhosis is associated with cardiac dysfunction, particularly left ventricular diastolic dysfunction, which worsens with increasing MELD score severity.
May support correlation of cirrhosis severity with cardiac dysfunction; leaves open need for prospective validation before clinical adoption.
Background: Recent research has increased amount of evidence for heart disease associated with cirrhosis, which has led to the definition of the entity cirrhotic cardiomyopathy. The present study was conducted with an objective to evaluate the clinical, biochemical, and echocardiographic evaluation of patients presenting with cirrhosis and to find its correlation between the severity of cirrhosis and cardiac dysfunction. Materials and Methods: The present study was a case–control study conducted from July 2021 to September 2022. All the cases were examined using two-dimensional echocardiography, electrocardiogram, and other laboratory parameters. The Model for End-stage Liver Disease (MELD) score was calculated for each of the cases. Results: Alcohol ingestion was the most common (76%) etiological factor associated with cirrhosis. There was a significant difference between the QTc interval among cases and controls and among the MELD score group. A significant difference was observed in the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), interventricular septal thickness (IVST), left atrial diameter, cardiac output (CO), E (Peak velocity flow in early diastole)/A (peak velocity flow in late diastole), E (Peak velocity in early diastole)/e’(passive left ventricular filling during early diastole), and deceleration time among the cases and controls. Conclusion: Based on our results, we conclude that liver cirrhosis cases revealed increased cardiac dysfunction with an increase in the MELD severity, particularly involving left ventricular diastolic dysfunction. Cirrhotic patients presented with increased CO and decreased E/A ratio. With increasing MELD score, there was a significant increase in the LVESD, LVEDD, IVST, and CO and a decreased E/A ratio.
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Chigullapalli et al. (2023) conducted a case-control in Cirrhosis. Cirrhosis vs. Controls was evaluated on Cardiac dysfunction (echocardiographic and electrocardiographic parameters). Cirrhosis was associated with significant cardiac dysfunction, including increased cardiac output and decreased E/A ratio compared to controls, which worsened with increasing MELD scores.
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