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January 1, 2023Annals of GastroenterologyOpen Access

A case-cohort study of left ventricular diastolic dysfunction in patients with cirrhosis: the liver–heart axis

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Why the study?

Left ventricular diastolic dysfunction is an early manifestation of cirrhotic cardiomyopathy, but few studies have addressed its clinical significance in cirrhosis.

Is left ventricular diastolic dysfunction associated with increased disease severity, complications, and poorer survival in patients with cirrhosis?

Population

203 cirrhosis patients

Comparison

139 patients with LVDD vs 64 patients without LVDD

Design

Case-cohort study

Authors

RSRushil Solanki

Discussion

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Overview

LVDD may aid prognostication in cirrhosis; hypothesis-generating for screening or intervention trials.

Structured PICO

Is left ventricular diastolic dysfunction associated with increased disease severity, complications, and poorer survival in patients with cirrhosis?

P
Population
203 patients with cirrhosis, mean age 52.76±10 years.
C
Comparator
Patients without left ventricular diastolic dysfunction (n=64)
O
Outcome
Association of left ventricular diastolic dysfunction with factors affecting cirrhosis patients' severity, complications, and survival

Left ventricular diastolic dysfunction in cirrhosis is independently associated with higher disease severity, specific complications like ascites, and poorer survival.

Cite This Study

Rushil Solanki (2023) studied this question.

synapsesocial.com/papers/6a8a768a5c716ca1a5d472dahttps://doi.org/10.20524/aog.2023.0837
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Predicting Cardiac Dysfunction in Patients with Liver Cirrhosis2021 · 7 citations
  2. 2Characteristics of Cirrhosis Patients With Left Ventricular Diastolic Dysfunction In China: A Single-Center Retrospective Study.2021 · 1 citations
  3. 3Association of left ventricular diastolic dysfunction with inflammatory activity, renal dysfunction, and liver-related mortality in patients with cirrhosis and ascites2024 · 4 citations
  4. 4Ultrasonographic Prevalence and Factors Predicting Left Ventricular Diastolic Dysfunction in Patients with Liver Cirrhosis: Is There a Correlation between the Grade of Diastolic Dysfunction and the Grade of Liver Disease?2012 · 25 citations
  5. 5Cardiac diastolic dysfunction predicts poor prognosis in patients with decompensated liver cirrhosis2018 · 36 citations