Key result
Two distinct DNA polymerases with viral RNA-directed DNA polymerase properties were identified in the placenta of a patient with breast cancer, whereas none were detected in normal placenta.
Population
Human placenta of a patient with breast cancer
Comparison
Purification by column-chromatographic… vs Normal human placenta
Design
Preclinical
Authors
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No clinical implications; leaves open potential retroviral polymerase activity in breast cancer placenta.
Identified and characterized two distinct reverse transcriptase-like enzymes in the placenta of a breast cancer patient that were absent in normal placenta.
Angelika Vogel (1981) studied Breast cancer (n=1). Biochemical analysis of placental tissue vs. Normal human placenta was evaluated on Presence and properties of reverse transcriptase enzymes. Two distinct DNA polymerases with viral RNA-directed DNA polymerase properties were identified in the placenta of a patient with breast cancer, whereas none were detected in normal placenta.
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