Key result
Rheumatoid arthritis was associated with an increased odds of non-fatal myocardial infarction (OR 2.50) and cardiovascular death (OR 1.99) compared to controls, though the results were not statistically significant.
Why the study?
Rheumatoid arthritis or its treatment can lead to atherosclerosis and involve the cardiovascular system, prompting assessment of cardiovascular event risks compared with the general population.
Does rheumatoid arthritis increase the risk of major adverse cardiovascular events compared to the general population?
Case-Control (n=415)
No
Does rheumatoid arthritis increase the risk of major adverse cardiovascular events compared to the general population?
Odds Ratio: 2.5 (95% CI 0.77–8.14)
Absolute Event Rate: 5.23% vs 1.95%
p-value: p=NS
Rheumatoid arthritis is associated with a numerically higher, though statistically non-significant, risk of myocardial infarction and cardiovascular death, highlighting the potential need for cardiovascular risk screening in these patients.
Non-significant MI and CV death elevation in RA; leaves open whether this supports enhanced cardiovascular screening in rheumatoid arthritis.
Introduction Rheumatoid arthritis is a chronic, inflammatory, and multisystem disease, which, along with the joints, can involve the cardiovascular system. The treatment of rheumatoid arthritis or rheumatoid arthritis itself can lead to atherosclerosis, which is considered one of the major causes by which it can affect the cardiovascular system. In this study, we will assess the risk of cardiovascular events in patients with rheumatoid arthritis as compared to the general population. Method This case-control study was conducted from January 2018 to November 2018. Two-hundred twenty-two (222) patients with diagnosed rheumatoid arthritis were included as cases in the study. Two-hundred eleven (211) patients were included in the study as the control group (patients without rheumatoid arthritis). All the data were recorded in a self-structured questionnaire. Result Participants with rheumatoid arthritis also showed an increased risk of myocardial infarction (MI) by an odds ratio of 2.50 (95% CI; 0.77-8.14). There was also an increased risk of cardiovascular death in participants with rheumatoid arthritis by an odds ratio of 1.99 (0.58-6.71). Conclusion The study suggests that rheumatoid arthritis along with joint inflammation can also affect the cardiovascular system. Hence, a multidisciplinary team of rheumatologists and cardiologists should manage patients suffering from rheumatoid arthritis, which will improve morbidity and mortality in such patients.
No takes yet. Share an insight, caveat, or question.
Mal et al. (2020) conducted a case-control in Rheumatoid arthritis (n=415). Rheumatoid arthritis vs. Patients without rheumatoid arthritis was evaluated on Non-fatal myocardial infarction (OR 2.50, 95% CI 0.77-8.14, p=NS). Rheumatoid arthritis was associated with an increased odds of non-fatal myocardial infarction (OR 2.50) and cardiovascular death (OR 1.99) compared to controls, though the results were not statistically significant.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: