Key result
Medical management resulted in survival and resolution of functional abnormalities in two neonates with severe persistent fetal circulation, myocardial dysfunction, and extreme acidemia.
Case Report (n=2)
Severe persistent fetal circulation presenting with myocardial dysfunction and extreme acidemia can be successfully treated with medical management, leading to resolution of functional abnormalities.
May support medical management in rare severe neonatal cases; hypothesis-generating and requires validation in larger studies.
Two neonates with the most severe form of persistent fetal circulation are described. Their presentation mimicked severe congenital heart disease. As well as persistent pulmonary hypertension and right-to-left shunting through the ductus arteriosus, they had poor myocardial contractility and atrioventricular valve regurgitation. Associated acidaemia was extreme. They survived with medical management, and the functional abnormalities resolved.
No takes yet. Share an insight, caveat, or question.
Dorothy J. Radford (1979) conducted a case report in Persistent fetal circulation (n=2). Medical management was evaluated on Survival and resolution of functional abnormalities. Medical management resulted in survival and resolution of functional abnormalities in two neonates with severe persistent fetal circulation, myocardial dysfunction, and extreme acidemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: