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From two commercially available starting materials, improved one‐step, multigram‐scale syntheses of [(IPr)Pd(acac)Cl] [IPr= N , N′ ‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene; acac=acetylacetonate] and [(IMes)Pd(acac)Cl] [IMes= N , N′ ‐bis(2,4,6‐trimethylphenyl)imidazol‐2‐ylidene] are described. The catalytic activity of both complexes in cross‐coupling reactions has been examined. The most active pre‐catalyst, [(IPr)Pd(acac)Cl], has allowed for efficient large‐scale (10 mmol) Buchwald–Hartwig and α‐ketone arylation reactions to be carried out.
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Marion et al. (2007) studied this question.
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