Key result
Thymosin Beta-4 (Tβ4) acts as a promising tissue repair stimulating protein that promotes cardiomyocyte survival and cardiac healing following myocardial infarction and other injuries.
Why the study?
Recent reports have suggested Thymosin Beta-4 as a promoter of cardiomyocyte survival and cardiac healing through activating resident epicardial progenitor cells and modulating inflammatory-caused injuries.
Does Thymosin Beta-4 promote cardiac healing and tissue repair following myocardial infarction?
Does Thymosin Beta-4 promote cardiac healing and tissue repair following myocardial infarction?
Thymosin Beta-4 shows promise as a therapeutic agent for cardiac healing and tissue repair following myocardial infarction.
Thymosin Beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis. Tβ4 is a water-soluble protein that has different promising clinical applications in the remodeling and ulcerated tissues repair following myocardial infarction, stroke, plasticity and neurovascular remodeling of the Peripheral Nervous System (PNS) and the Central Nervous System (CNS). On the other hand, similar effects have been observed for Tβ4 in other kinds of tissues, including cardiac muscle tissue. In recent reports, as it activates resident epicardial progenitor cells and modulates inflammatory-caused injuries, Tβ4 has been suggested as a promoter of the survival of cardiomyocytes. Furthermore, Tβ4 may act in skeletal muscle and different organs in association/synergism with numerous other tissue repair stimulating factors, including melatonin and C-fiber-derived peptides. For these reasons, the present review highlights the promising role of Tβ4 in cardiac healing.
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Bjørklund et al. (2019) conducted a review in Heart injury. Thymosin Beta-4 (Tβ4) was evaluated. Thymosin Beta-4 (Tβ4) acts as a promising tissue repair stimulating protein that promotes cardiomyocyte survival and cardiac healing following myocardial infarction and other injuries.
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