What question did this study set out to answer?

To assess whether dietary yeast-derived glucomannan supplementation mitigates the adverse effects of aflatoxin B1 and T-2 toxin on vaccinal immune responses and drug-metabolising liver enzymes in weaned pigs.

May 1, 2009World Mycotoxin Journal

Dietary glucomannan improves the vaccinal response in pigs exposed to aflatoxin B1 or T-2 toxin

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To assess whether dietary yeast-derived glucomannan supplementation mitigates the adverse effects of aflatoxin B1 and T-2 toxin on vaccinal immune responses and drug-metabolising liver enzymes in weaned pigs.
Fed weaned pigs three doses of aflatoxin B1 (482, 968, and 1,912 µg/kg feed) or T-2 toxin (593, 1,155, and 2,067 µg/kg feed) with or without 2 g/kg dietary glucomannan for 28 days.
Immunised pigs with ovalbumin on days 4 and 15 to evaluate antigen-specific cellular and humoral immune responses alongside phase I liver enzyme activities.
Glucomannan restored delayed ovalbumin-specific lymphocyte proliferation across all aflatoxin B1 doses and decreased liver lesion severity at 968 µg/kg feed.
Glucomannan supplementation restored anti-ovalbumin immunoglobulin G production, which was significantly suppressed at medium and high doses of T-2 toxin, while showing limited protection against toxin-induced impairment of phase I liver enzymes.

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Implication

Experimental trial demonstrates restored vaccine responses in mycotoxin-exposed pigs, indicating glucomannan protects against immunotoxicity.

Cite This Study

Meissonnier et al. (2009) studied this question.

synapsesocial.com/papers/6a9f573bee494a071104ec2f https://doi.org/10.3920/wmj2008.1127

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Implication

Experimental trial demonstrates restored vaccine responses in mycotoxin-exposed pigs, indicating glucomannan protects against immunotoxicity.

Dietary glucomannan improves the vaccinal response in pigs exposed to aflatoxin B1 or T-2 toxin

Key Points

Discussion

Implication

Cite This Study

Dietary glucomannan improves the vaccinal response in pigs exposed to aflatoxin B1 or T-2 toxin

Key Points

Discussion

Implication

Cite This Study

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