Key result
Thiazide diuretic and beta-blocker use were independently associated with a higher risk of incident type 2 diabetes compared with non-use (RR 1.20-1.45 for thiazides; RR 1.20-1.32 for beta-blockers).
Why the study?
Does the use of different classes of antihypertensive medications increase the risk of incident type 2 diabetes in patients with hypertension?
Population
n=74,816 adults with hypertension and no history of diabetes at baseline.
Comparison
Use of different classes of antihypertensive… vs Participants not taking the specific class of…
Design
Cohort
Follow-up
8, 10, and 16 years, respectively for the three cohorts
Authors
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Thiazide and beta-blocker use was associated with higher diabetes risk; extends observational data but leaves causal effects and practice change open.
Cohort (n=74,816)
Does the use of different classes of antihypertensive medications increase the risk of incident type 2 diabetes in patients with hypertension?
Relative Risk: 1.2 (95% CI 1.08–1.33)
Thiazide diuretics and beta-blockers are independently associated with an increased risk of incident type 2 diabetes in hypertensive patients, suggesting a need for increased surveillance.
Eric N. Taylor (2006) conducted a cohort in hypertension (n=74,816). Thiazide diuretics and beta-blockers vs. Non-use of the respective medication was evaluated on incident type 2 diabetes (RR 1.20, 95% CI 1.08-1.33). Thiazide diuretic and beta-blocker use were independently associated with a higher risk of incident type 2 diabetes compared with non-use (RR 1.20-1.45 for thiazides; RR 1.20-1.32 for beta-blockers).
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