Animal study reveals that Peucedanum japonicum Thunb extract improves insulin sensitivity and reduces lipid accumulation in ob/ob mice, suggesting therapeutic potential for metabolic disorders.
Aim of the study is to evaluate the anti-diabetic activity of PJT. This study examined its anti-obesity activity in obese-diabetic animal model of C57BL/6J Ham Slc-ob/ob mice. By dividing animals into control and ethanol extract of PJT groups, body weight gain, tissue weight, biochemical parameters in serum, liver, fecal lipid concentrations and gene expression in the tissues were compared between control and PJT extract groups after been fed with the basal low-fat diet supplemented with or without PJT extract for four weeks. The results show that supplementation of the diet with ethanol extract of PJT significantly reduced white adipose tissue (WAT), serum triglyceride (TG), total cholesterol (TC) and adipocyte size. The ethanol extracts also significantly increase insulin sensitivity, fecal excretion of TG, TC, and decreased that of bile acid. The ethanol extract of PJT modulated the obesity related genes in liver, adipose tissues of ob/ob mice: upregulation of PBEF1, PPARα, and downregulation of FAS genes in the liver; upregulation of RORC, DGAT1, FXRα, PPARγ genes in the adipose tissue; increased expression of CPT1α, UCP2 and GLUT4 genes in muscle. In conclusion, it is suggested that ethanol extract of PJT exerted anti-diabetic activity through the modulation of obesity-related lipid parameters in obese-diabetic animal model.
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Nukitrangsan et al. (2012) studied this question.
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