Answers are grounded in this paper and cite their sources.
The in-vitro lipophilicity of nine beta-adrenoceptor antagonists was evaluated based on retention on a reverse-phase C-18 high-pressure liquid chromatographic (hplc) system at physiologic pH. Propranolol was by far the most lipophilic drug, while atenolol and sotolol were the least. Hplc retention was highly correlated (r = 0.92) with octanol: buffer partition coefficient. Thus hplc retention is a rapid and replicable approach to the determination of in-vitro lipophilicity that does not require radioactive drug.
No takes yet. Share an insight, caveat, or question.
Arendt et al. (1984) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: