Key result
The coexistence of heart failure and chronic kidney disease in patients with type 2 diabetes significantly increases mortality risk and requires a comprehensive interdisciplinary therapeutic approach.
Concomitant heart failure and chronic kidney disease in type 2 diabetes significantly increase mortality risk and require a comprehensive interdisciplinary therapeutic approach.
Complex hemodynamic, neurohormonal and biochemical changes occur in heart failure and chronic kidney disease, and hyperglycemia/diabetes further accentuate the multifactorial pathogenetic mechanisms. The acknowledgement of concomitant heart and kidney dysfunction in patients with type 2 diabetes has major clinical implications with regards to prognosis, as they significantly increase the risk of mortality, and to therapeutical strategy of both conditions, as well as of hyperglycemia. A comprehensive interdisciplinary approach is needed in these cases in order to improve the outcomes.
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Simona Cernea (2016) conducted a review in Type 2 diabetes, heart failure, and chronic kidney disease. The coexistence of heart failure and chronic kidney disease in patients with type 2 diabetes significantly increases mortality risk and requires a comprehensive interdisciplinary therapeutic approach.
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