Key result
Incident CKD or HF in new-onset T2DM is linked to ~3-fold greater mortality risk.
Why the study?
The study was designed to investigate the interplay of incident chronic kidney disease and heart failure and their associations with prognosis in patients with type 2 diabetes.
Does incident CKD and/or HF increase mortality risk in patients with new-onset T2DM?
Cohort (n=102,488)
Does incident CKD and/or HF increase mortality risk in patients with new-onset T2DM?
Effect estimate: three-fold hazard
In patients with new-onset T2DM, incident CKD and HF frequently complicate each other and their concomitant presence confers a 6- to 7-fold increased risk of mortality.
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Incident CKD/HF signals up to 7-fold higher mortality in new-onset T2DM; extends cardiorenal observations but leaves causal pathways and interventions open.
Wu et al. (2022) conducted a cohort in type 2 diabetes (n=102,488). Incident chronic kidney disease (CKD) and/or heart failure (HF) vs. CKD/HF-free status was evaluated on incident CKD and/or HF and all-cause mortality (three-fold hazard). Among patients with new-onset T2DM, incident CKD or HF was associated with a 3-fold hazard of death, while concomitant HF and CKD conferred a 6- to 7-fold adjusted hazard of mortality.
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