Key result
Incident IHD and ESRD in T2D linked to ~392% greater 5-year HF risk.
Why the study?
To evaluate the risk of heart failure in patients with type 2 diabetes complicated by development of intercurrent ischaemic heart disease, end-stage renal disease, or both.
Does the development of intercurrent ischaemic heart disease, end-stage renal disease, or both increase the risk of incident heart failure in patients with new-onset type 2 diabetes?
Population
285 024 patients with new-onset T2D and no history of HF in Denmark
Comparison
Intercurrent IHD, ESRD, or both vs no IHD and ESRD
Design
Nationwide registry-based cohort study
Follow-up
5 years
Authors
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Closer HF surveillance may be warranted in T2D with incident IHD or ESRD; leaves open whether prevention alters outcomes.
Cohort (n=285,024)
Yes
Does the development of intercurrent ischaemic heart disease, end-stage renal disease, or both increase the risk of incident heart failure in patients with new-onset type 2 diabetes?
Effect estimate: RR 4.92 (95% CI 3.43-7.05)
Absolute Event Rate: 19.76% vs 4.02%
p-value: p=< 0.001
In patients with type 2 diabetes, the development of ischemic heart disease and/or end-stage renal disease significantly increases the subsequent risk of incident heart failure.
Malik et al. (2020) conducted a cohort in Type 2 diabetes (n=285,024). Incident ischaemic heart disease and end-stage renal disease vs. No ischaemic heart disease and no end-stage renal disease was evaluated on 5-year absolute risk of heart failure (RR 4.92, 95% CI 3.43-7.05, p=< 0.001). Incident ischaemic heart disease and end-stage renal disease in type 2 diabetes significantly increased the 5-year risk of heart failure compared to neither condition (RR 4.92; 95% CI 3.43-7.05).
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