Key result
A higher pre-transplant Angiopoietin-2 index was an independent risk factor for the development of acute graft-versus-host disease after hematopoietic stem cell transplantation (OR 2.25).
Why the study?
Angiogenic factors released under endothelial stress reflect tissue healing or tissue damage, prompting investigation into whether pre-transplant levels are associated with acute graft-versus-host disease risk.
Is the pre-transplant Angiopoietin-2 index associated with the risk of acute graft-versus-host disease after hematopoietic stem cell transplantation?
Cohort (n=37)
No
Is the pre-transplant Angiopoietin-2 index associated with the risk of acute graft-versus-host disease after hematopoietic stem cell transplantation?
Pre-transplant Angiopoietin-2 index may serve as a biomarker to estimate the risk of developing acute graft-versus-host disease following hematopoietic stem cell transplantation.
Answers are grounded in this paper and cite their sources.
Pre-transplant Ang2 index may flag aGvHD risk before conditioning; leaves open validation in larger prospective cohorts.
Objective: Angiogenic factors (AFs) released under endothelial stress are reflective of tissue healing, while some may also contribute to tissue damage/inflammation. We investigated whether alterations in the pre-transplant levels of AFs were associated with the risk of acute graft-versus-host disease (aGvHD). Materials and Methods: The pre-conditioning plasma levels of angiopoietin-2 (Ang2), endoglin, and follistatin were measured for 37 patients together with inflammatory markers. The index values defined were evaluated to better identify the alterations. Results: The patients had higher pre-conditioning levels of Ang2, endoglin, and follistatin compared to controls. The patients with aGvHD had higher Ang2 index and lower albumin index scores in comparison to those without aGvHD. Multivariate analysis revealed that the pre-transplant Ang2 index was an independent risk factor for aGvHD development. Conclusion: Pre-transplant evaluation of plasma Ang2 levels along with inflammatory status even before conditioning is associated with endothelial vulnerability. The pre-transplant Ang2 index could be a promising candidate to estimate the risk of aGvHD.
No takes yet. Share an insight, caveat, or question.
Şatırer et al. (2021) conducted a cohort in Hematopoietic stem cell transplantation (n=37). Pre-transplant Angiopoietin-2 index vs. Lower pre-transplant Angiopoietin-2 index was evaluated on Development of acute graft-versus-host disease (aGvHD) (OR 2.25, 95% CI 1.03-4.9, p=0.04). A higher pre-transplant Angiopoietin-2 index was an independent risk factor for the development of acute graft-versus-host disease after hematopoietic stem cell transplantation (OR 2.25).
Synapse has enriched 10 related papers. Consider them for comparative context: