Key result
Higher total dietary flavonoid intake was associated with a significantly lower risk of non-alcoholic fatty liver disease progression (RR 0.71) compared to the lowest intake quintile over 3 years.
Why the study?
Flavonoid-rich foods show benefits against NAFLD in short-term trials, but whether usual dietary flavonoid intake benefits patients with NAFLD was uncertain.
Does higher dietary flavonoid intake reduce the risk of NAFLD progression in adults?
Population
2694 adults from the Guangzhou Nutrition and Health Study
Comparison
Higher vs lower habitual dietary intake of flavonoids
Design
Prospective study
Follow-up
3 years
Authors
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Higher flavonoid intake was associated with lower NAFLD progression risk; hypothesis-generating and requires RCTs before any practice change.
Cohort (n=2,694)
Does higher dietary flavonoid intake reduce the risk of NAFLD progression in adults?
Relative Risk: 0.71 (95% CI 0.54–0.93)
p-value: p=0.012
Higher habitual dietary intake of flavonoids is associated with a significantly lower risk of NAFLD progression in middle-aged and elderly Chinese adults, potentially mediated by improvements in insulin resistance and serum cholesterol.
Zhong et al. (2020) conducted a cohort in Non-alcoholic fatty liver disease (NAFLD) (n=2,694). Higher dietary flavonoid intake vs. Lowest quintile of dietary flavonoid intake was evaluated on Progression (worsening) of NAFLD status (RR 0.71, 95% CI 0.54-0.93, p=0.012). Higher total dietary flavonoid intake was associated with a significantly lower risk of non-alcoholic fatty liver disease progression (RR 0.71) compared to the lowest intake quintile over 3 years.