Review: After stroke or TIA, adding clopidogrel to aspirin for ≤ 1 month reduces recurrence and MACE

ACP Journal Club20 August 2019Review: After stroke or TIA, adding clopidogrel to aspirin for ≤ 1 month reduces recurrence and MACEGraeme J. Hankey, MD, FRACPGraeme J. Hankey, MD, FRACPThe University of Western Australia, Perth, Western Australia, Australia (G.J.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ201908200-014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationRahman H, Khan SU, Nasir F, et al. Optimal duration of aspirin plus clopidogrel after ischemic stroke or transient ischemic attack. Stroke. 2019;50:947-53. https://pubmed.ncbi.nlm.nih.gov/30852971Clinical Impact RatingsGIM/FP/GP: Hospitalists: Neurology: References1 Sandercock PA, Counsell C, Tseng MC, Cecconi E. Oral antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev. 2014;3:CD000029. [PMID: 24668137] Google Scholar2 Johnston SC, Amarenco P, Albers GW, et al; SOCRATES Steering Committee and Investigators. Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med. 2016;375:35-43. [PMID: 27160892] Google Scholar3 Yang Y, Zhou M, Zhong X, et al. Dual versus mono antiplatelet therapy for acute non-cardioembolic ischaemic stroke or transient ischaemic attack: a systematic review and meta-analysis. Stroke Vasc Neurol. 2018;3:107-16. [PMID: 30022798] Google Scholar4 Bath PM, Woodhouse LJ, Appleton JP, et al. Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT. Health Technol Assess. 2018;22:1-76. [PMID: 30179153] Google Scholar5 Hao Q, Tampi M, O’Donnell M, et al. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ. 2018;363:k5108. [PMID: 30563866] Google Scholar Author, Article, and Disclosure InformationAffiliations: The University of Western Australia, Perth, Western Australia, Australia (G.J.H.)This article was published at Annals.org on 6 August 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury 20 August 2019Volume 171, Issue 4Page: JC14KeywordsAspirinHemorrhageIschemic strokeMortalityMyocardial infarctionRisk ratioSafetyStrokeTransient ischemic attacks ePublished: 20 August 2019 Issue Published: 20 August 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...