Key result
Cr51-labeled platelets mildly damaged by immunologic means were slowly destroyed in the spleen, whereas severely damaged cells were rapidly removed from the circulation by the liver.
Population
Patients with idiopathic thrombocytopenic purpura, congestive splenomegaly, idiopathic thrombocythemia, and…
Design
Other
Follow-up
up to 9 days
Authors
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Severity of immunologic platelet sensitization may determine sequestration site; leaves open whether this informs management of antibody-mediated thrombocytopenia.
Observational (n=11)
No
The study demonstrates that the degree of platelet sensitization by isoantibodies determines the primary site of sequestration, with mild sensitization leading to splenic trapping and severe sensitization causing rapid hepatic clearance.
Aster et al. (1964) conducted an observational in Idiopathic thrombocytopenic purpura and isoimmunity (n=11). Cr51-labeled platelet transfusion and isoantibody injection was evaluated on Platelet survival (half-disappearance time) and site of sequestration. Cr51-labeled platelets mildly damaged by immunologic means were slowly destroyed in the spleen, whereas severely damaged cells were rapidly removed from the circulation by the liver.
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