Key result
Poor sleep quality was significantly associated with moderate-to-severe global cortical atrophy in older adults (OR 0.09, p=0.004), with the probability significantly increasing in those aged ≥67 years.
Why the study?
Is poor sleep quality associated with global cortical atrophy in older adults?
Population
290 community-dwellers aged ≥ 60 years enrolled in the Atahualpa Project
Comparison
Poor sleep quality vs Good sleep quality (implied)
Design
Cross-sectional
Authors
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Hypothesis-generating for sleep as atrophy risk factor; prospective studies needed before any clinical adoption in older adults.
Cross-Sectional (n=290)
Single-blind
No
Is poor sleep quality associated with global cortical atrophy in older adults?
Odds Ratio: 0.09 (95% CI 0.02–0.46)
Absolute Event Rate: 57% vs 45%
p-value: p=0.004
Poor sleep quality is associated with global cortical atrophy in older adults, with the risk increasing significantly after age 67.
Brutto et al. (2016) conducted a cross-sectional in Community-dwelling older adults (n=290). Poor sleep quality vs. Good sleep quality was evaluated on Moderate-to-severe global cortical atrophy (GCA) (OR 0.09, 95% CI 0.02-0.46, p=0.004). Poor sleep quality was significantly associated with moderate-to-severe global cortical atrophy in older adults (OR 0.09, p=0.004), with the probability significantly increasing in those aged ≥67 years.
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