Vascular biomarkers: research methods, indicators, clinical, prognostic value and perspectives

The article deals with modern terminology, methods of studying of the rigidity of blood vessels, their diagnostic value. Taking into account the class and level of evidence, a modern understanding of the diagnostic significance, sensitivity of methods for the study of vessel rigidity has been offered. The role of vascular biomarkers in patients with various diseases is considered. The potential for therapeutic effects on vascular biomarkers has been observed based on the latest consensus documents, meta-analyses. The issue that has not yet been included in the consensus documents — the relationship between vessel rigidity and cognitive impairments — is considered separately. The role of vascular rigidity in the development of the syndrome of small cognitive impairments and the possibility of their therapeutic correction have been demonstrated. In conclusion, the authors state that for today a huge work has been done to study the rigidity of blood vessels, which allowed the creation of general consensus documents. Various scientific researches using non-invasive methods for the study of vascular rigidity, which is of fundamental importance in the selection of pharmacological therapy, seem promising. The practitioner should be informed in the problem of vascular biomarkers in order to evaluate these studies.