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January 1, 2001Chemical and Pharmaceutical BulletinOpen Access

Synthesis and Anti-HIV-1 Activity of New Delavirdine Analogues Carrying Arylpyrrole Moieties.

Gérard A. Pinna Giovanni Loriga Gabriele Murineddu G. Grella Massimo Mura Laura Vargiu Chiara Murgioni Paolo La Colla

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Abstract

In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.

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Pinna et al. (2001) studied this question.

synapsesocial.com/papers/6a9f75aa6b2f41ee0d04f03e https://doi.org/10.1248/cpb.49.1406

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