Key result
Vitamin K at 2.3 micromol/L significantly increased monophasic action potential duration by 6.5 msec (P<0.05) and reduced sodium and potassium currents in guinea pig hearts.
Why the study?
Does vitamin K modulate cardiac action potentials and ion currents in guinea pig hearts?
Population
Guinea pig hearts (n = 21) and ventricular myocytes
Design
Preclinical
Authors
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May link rapid vitamin K to arrhythmias via ion channel effects in animals; leaves open human relevance.
Does vitamin K modulate cardiac action potentials and ion currents in guinea pig hearts?
p-value: p=<.05
Intravenous vitamin K at therapeutic concentrations modulates cardiac action potentials by blocking sodium and potassium channels, providing a potential mechanism for adverse cardiovascular events associated with its rapid administration.
Drolet et al. (2000) studied this question. Vitamin K was evaluated on Monophasic action potential duration measured at 90% repolarization (MAPD(90)) and ion channel currents (p=<.05). Vitamin K at 2.3 micromol/L significantly increased monophasic action potential duration by 6.5 msec (P<0.05) and reduced sodium and potassium currents in guinea pig hearts.
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