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December 1, 2004Angewandte Chemie

A Stereodivergent Synthesis of Virantmycin by an Enzyme‐Mediated Diester Desymmetrization and a Highly Hindered Aryl Amination

Thomas G. Back Jeremy E. Wulff

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Abstract

Beide Enantiomere des Antivirusmittels Virantmycin wurden in einer Reaktionsfolge erhalten, deren Schlüsselschritte eine hoch stereoselektive, durch Schweineleber-Esterase (PLE) vermittelte Desymmetrisierung eines prochiralen Diesters und eine bemerkenswert effektive intramolekulare Arylaminierung eines ortho-substituierten Arylbromids mit einem stark gehinderten α-quartären Formamid sind (siehe Retrosyntheseschema).

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Back et al. (2004) studied this question.

synapsesocial.com/papers/6a9f78f2accb0daecaf7e129 https://doi.org/10.1002/ange.200461327

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