What question did this study set out to answer?

To compare tumor control rates and treatment-related toxicities between basal and nonbasal meningiomas treated with single-fraction Gamma Knife radiosurgery.

January 1, 1999Stereotactic and Functional Neurosurgery

A Comparison of Single Fraction Radiosurgery Tumor Control and Toxicity in the Treatment of Basal and Nonbasal Meningiomas

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Authors

SVSandra VermeulenGGz centraal RYRonald F. YoungLaboratoire de Météorologie Dynamique FLF. LiArmy Medical University

Discussion

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Implication

Cohort study reveals comparable tumor control but higher symptomatic edema for nonbasal meningiomas treated with radiosurgery, suggesting alternative therapies for nonbasal locations.

Key Points

To compare tumor control rates and treatment-related toxicities between basal and nonbasal meningiomas treated with single-fraction Gamma Knife radiosurgery.
Retrospective cohort analysis of 107 patients with 118 meningiomas (54% skull base; mean diameter 2.5 cm, volume 9.4 cm³) treated between July 1993 and October 1997.
Patients received single-fraction Gamma Knife radiosurgery at a mean peripheral dose of 17 Gy prescribed to a mean 47% isodose line, with outcomes assessed over a mean follow-up of 28 months.
Tumor control was 80% for both basal and nonbasal meningiomas at a mean follow-up of 28 months.
Symptomatic deteriorating peritumoral edema occurred in 2% (1 of 49) of skull-base tumors compared with 10% (4 of 39) of nonbasal tumors without evidence of tumor growth (p=0.15 and p=0.234, respectively).

Cite This Study

Vermeulen et al. (1999) studied this question.

synapsesocial.com/papers/6a9f78f863dc1fb3bd892383 https://doi.org/10.1159/000056440

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Implication

Cohort study reveals comparable tumor control but higher symptomatic edema for nonbasal meningiomas treated with radiosurgery, suggesting alternative therapies for nonbasal locations.

A Comparison of Single Fraction Radiosurgery Tumor Control and Toxicity in the Treatment of Basal and Nonbasal Meningiomas

Discussion

Member takes

Implication

Key Points

Cite This Study

A Comparison of Single Fraction Radiosurgery Tumor Control and Toxicity in the Treatment of Basal and Nonbasal Meningiomas

Discussion

Member takes

Implication

Key Points

Cite This Study

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