Key result
The addition of Mean Platelet Volume to the GRACE score increased the predictive value for major cardiovascular events during hospitalization, improving the AUC from 0.786 to 0.810.
Why the study?
Risk stratification in ACS is performed using the GRACE score, but whether adding mean platelet volume (MPV) increases its predictive value for major cardiovascular events during in-hospital care is unknown.
Does the addition of Mean Platelet Volume (MPV) to the GRACE score improve the prediction of major cardiovascular events in ACS patients during in-hospital care?
Cohort (n=219)
No
Does the addition of Mean Platelet Volume (MPV) to the GRACE score improve the prediction of major cardiovascular events in ACS patients during in-hospital care?
Adding Mean Platelet Volume to the GRACE score slightly improves the predictive value for major cardiovascular events during in-hospital care for ACS patients.
Answers are grounded in this paper and cite their sources.
MPV addition to GRACE may refine ACS risk stratification; hypothesis-generating and requires prospective validation before practice change.
Background: Acute Coronary Syndrome (ACS) is a term used to describe symptoms caused by Acute Myocardial Infarction (AMI).At present, risk stratification is carried out with the use of a Global Registry of Acute Coronary Events (GRACE) score as a validated predictor for cardiovascular events among ACS patients.Mean platelet volume (MPV) is an accurate marker of platelet size and can be considered that to be added to the GRACE score to increase the predictive value of the occurrence of major cardiovascular events (MACE).This study aims to seek the comparison between GRACE score independently and GRACE score with the addition of MPV values in predicting major cardiovascular events during in-hospital care in ACS patients.Methods: This study was ambispective cohort study of 219 ACS patients from November 2017 to November 2018.GRACE scores and MPV values were calculated and mace was observed during hospital treatment.An analysis was performed to see the role of MPV addition to GRACE scores in predicting MACE.Results: MPV values and GRACE scores were found to be increased in patients with MACE compared with those who did not.Area under curve (AUC) on the ROC curve obtained 0.786 (95% CI: 0.717-0.855,p<0.001) when the GRACE score was calculated independently, and increased to 0.810 (95% CI: 0.620-0.775,p<0.001) with addition MPV which indicates a combination of MPV and GRACE score increases predictive value.Conclusion: The addition of the MPV value to the GRACE score provides a higher predictive value in predicting MACE in ACS patients in hospital care.
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Delfian et al. (2019) conducted a cohort in Acute Coronary Syndrome (ACS) (n=219). Addition of Mean Platelet Volume (MPV) to GRACE score vs. GRACE score independently was evaluated on Prediction of major cardiovascular events (MACE) (AUC) (AUC 0.810, 95% CI 0.744-0.876, p=<0.001). The addition of Mean Platelet Volume to the GRACE score increased the predictive value for major cardiovascular events during hospitalization, improving the AUC from 0.786 to 0.810.
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