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March 26, 2020Experimental and Therapeutic MedicineOpen Access

Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST‑segment elevation myocardial infarction after percutaneous coronary intervention

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Why the study?

Whether combining the GRACE risk score with the mean platelet volume to lymphocyte count ratio improves prediction of adverse clinical outcomes in STEMI had not been previously evaluated.

Does the combination of GRACE risk score and MPVLR improve prediction of 30-day MACE in patients with STEMI after PCI?

Population

464 patients with STEMI undergoing PCI

Comparison

Four groups stratified by GRACE risk score and MPVLR cut-off values

Follow-up

30-day

Authors

XCXinsen ChenShihezi UniversityMSMeng ShaoMarine Biomedical Research Institute of QingdaoTZTian Zhang

Discussion

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Implication

May aid 30-day MACE risk stratification in STEMI post-PCI; hypothesis-generating and requires prospective validation.

Structured PICO

Does the combination of GRACE risk score and MPVLR improve prediction of 30-day MACE in patients with STEMI after PCI?

P
Population
464 patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI)
I
Intervention
Combination of GRACE risk score and mean platelet volume to lymphocyte count ratio (MPVLR)
C
Comparator
Individual GRACE score and MPVLR, or low MPVLR + low GRACE score group
O
Outcome
30-day major adverse cardiovascular events (MACE)composite

The combination of GRACE risk score and MPVLR provides improved prognostic accuracy for 30-day MACE in STEMI patients undergoing PCI compared to either marker alone.

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/6a8491bcf6d812dcfa83e7a7https://doi.org/10.3892/etm.2020.8626
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study2016 · 47 citations
  2. 2Improved risk stratification of patients with acute coronary syndromes using a combination of hsTnT, NT-proBNP and hsCRP with the GRACE score2016 · 83 citations
  3. 3Effect of Prodromal Angina Pectoris on the Infarct Progression in Patients With First ST-Elevation Acute Myocardial Infarction2010 · 18 citations
  4. 4TIMI and GRACE Risk Scores Predict Both Short-Term and Long-Term Outcomes in Chinese Patients with Acute Myocardial Infarction.2018 · 48 citations
  5. 5Performance of the GRACE scores in a New Zealand acute coronary syndrome cohort2014 · 28 citations