Key result
The most appropriate QT correction formula for children and adolescents was found to be QTc=QT/RR0.38, demonstrating that adult correction methods do not apply.
Why the study?
What is the most appropriate QT correction formula for children and adolescents?
Meta-Analysis (n=2,288)
What is the most appropriate QT correction formula for children and adolescents?
QT correction methods developed for adults do not apply to children, highlighting the need for age- and gender-specific correction formulas such as QTc=QT/RR0.38.
Clinicians should use QTc=QT/RR^0.38 for pediatric QT correction; meta-analysis confirms adult formulas are invalid and supports age-specific standards.
INTRODUCTION: Accurate determination of the QTc interval has become increasingly important in the assessment of a drug's ability to prolong cardiac repolarization. Previous work suggests the most appropriate correction formula for adults is QTc=QT/RR0.40, but little on correction methods for children and adolescents has been published. METHODS AND RESULTS: In this study, ECG data were obtained from a meta-analysis of seven clinical trials for attention deficit/hyperactivity disorder (ADHD) involving 2,288 children and adolescents. The most appropriate formula for children and adolescents included in this database was found to be QTc=QT/RR0.38. Adjustments of the correction factor specifically for males and females of different ages also are reported. CONCLUSION: QT correction methods developed for adults do not apply to children. As accurate QTc determination plays a larger role in assessing a drug's potential to retard repolarization, use of age- and gender-specific correction formulas becomes more important.
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Wernicke et al. (2005) conducted a meta-analysis in Attention deficit/hyperactivity disorder (ADHD) (n=2,288). QT correction formula QTc=QT/RR0.38 was evaluated on Most appropriate QT correction formula. The most appropriate QT correction formula for children and adolescents was found to be QTc=QT/RR0.38, demonstrating that adult correction methods do not apply.
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