All articles of this category The first total synthesis of two natural 6- C -prenylflavanones, (±)-6- C -prenyleriodoctyol (1) and 6- C -prenylnaringenin (2) , using the acetophenone derivative 6 as the key intermediate is described. This new efficient synthetic approach was mainly based on Claisen rearrangement and cyclization reaction. 6- C -prenylflavanones - Claisen rearrangement - cyclization 2,4-bis(methoxymethoxy)-6-hydroxy-3-prenylacetophenone
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Bu et al. (1997) studied this question.