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Topiramate is a well-known medication used for migraine and epilepsy. Bleeding is a rare and less documented side-effect of this treatment. The authors present a rare case of bleeding in a patient who was started on topiramate, which was likely due to a vitamin K-dependent factor deficiency. Clinicians should take caution if any bleeding event is noted in patients on topiramate, and stop administering this drug.
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Gouli et al. (2025) studied this question.
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