Key result
Intracavernosal injection of COMP-Ang1 significantly restored PECAM-1 and VEGF protein expression to control levels in a dose-dependent manner, enhancing cavernous angiogenesis in a type 2 diabetic rat model.
Why the study?
Does intracavernosal injection of COMP-Ang1 improve cavernous angiogenesis in a type 2 diabetic rat model?
Does intracavernosal injection of COMP-Ang1 improve cavernous angiogenesis in a type 2 diabetic rat model?
p-value: p=<0.05
Intracavernosal injection of COMP-Ang1 enhances cavernous angiogenesis in a diabetic rat model, suggesting a potential therapeutic approach for diabetic erectile dysfunction.
Should not change practice; hypothesis-generating for COMP-Ang1 in diabetic ED.
Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is an angiogenic factor for vascular angiogenesis. The aim was to investigate the effect of an intracavernosal injection of COMP-Ang1 on cavernosal angiogenesis in a diabetic rat model. Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats made up the experimental group (1 yr old) and Long-Evans Tokushima Otsuka (LETO) rats made up the control group. The experimental group was divided into vehicle only, 10 µg COMP-Ang1, and 20 µg COMP-Ang1. COMP-Ang1 was injected into the corpus cavernosum of the penis. After 4 weeks, the penile tissues of the rats were obtained for immunohistochemistry and Western blot analysis. The immunoreactivity of PECAM-1 and VEGF was increased in the COMP-Ang1 group compared with the vehicle only group. Moreover, the expression of PECAM-1 and VEGF was notably augmented in the 20 µg Comp Ang-1 group. In the immunoblotting study, the expression of PECAM-1 and VEGF protein was significantly less in the OLEFT rats than in the control LETO rats. However, this expression was restored to control level after intracavernosal injection of COMP-Ang1. These results show that an intracavernosal injection of COMP-Ang1 enhances cavernous angiogenesis by structurally reinforcing the cavernosal endothelium.
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Kim et al. (2013) studied Type 2 diabetes-induced erectile dysfunction (animal model) (n=32). COMP-Angiopoietin-1 (COMP-Ang1) vs. Vehicle only (PBS plus 0.1% bovine serum albumin) was evaluated on Cavernosal angiogenesis assessed by PECAM-1 and VEGF protein expression (p=<0.05). Intracavernosal injection of COMP-Ang1 significantly restored PECAM-1 and VEGF protein expression to control levels in a dose-dependent manner, enhancing cavernous angiogenesis in a type 2 diabetic rat model.
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