Key result
Pigs vaccinated with 8.0 log10 TCID50/mL inactivated PEDV showed significantly higher FFN titers, FMIA, and ELISA values compared to 6.0 log10 TCID50/mL vaccinates and negative controls (p<0.05).
Why the study?
Does an inactivated PEDV vaccine improve humoral immune response in five week old pigs?
Population
Five week old pigs
Comparison
Inactivated adjuvanted monovalent PEDV vaccine… vs Negative controls and lower dose
Design
Preclinical
Authors
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Supports dose-optimized inactivated PEDV vaccines in young pigs; hypothesis-generating for field efficacy trials.
Does an inactivated PEDV vaccine improve humoral immune response in five week old pigs?
Absolute Event Rate: 7.32% vs 1.93%
p-value: p=<0.05
An inactivated PEDV vaccine using a U.S. strain is immunogenic in pigs, with higher doses eliciting significantly stronger humoral immune responses.
Collin et al. (2015) studied Porcine epidemic diarrhea virus (PEDV) vaccination (n=60). Inactivated PEDV vaccine (NPL PEDV 2013 P10.1) vs. Non-vaccinated control was evaluated on Humoral immune response (FFN titers, FMIA, and ELISA values) (p=<0.05). Pigs vaccinated with 8.0 log10 TCID50/mL inactivated PEDV showed significantly higher FFN titers, FMIA, and ELISA values compared to 6.0 log10 TCID50/mL vaccinates and negative controls (p<0.05).
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