Key result
Left ventricular pressure decay parameters showed higher beat-to-beat variability (e.g., T 4.7%, P<0.005) than standard hemodynamic parameters like dP/dtmax (1.9%) in normal dog hearts.
Population
9 chronically instrumented dogs
Design
Preclinical
Authors
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LV pressure decay variability cautions against single-beat measures in research; leaves open Ravg utility and human translation.
Absolute Event Rate: 4.7% vs 1.9%
p-value: p=<0.005
Left ventricular pressure decay exhibits marked beat-to-beat variability, and the model-independent parameter Ravg may be a useful method to quantify LV pressure fall.
Freeman et al. (1993) studied Normal heart (animal model) (n=9). Left ventricular pressure decay parameters (T, T1/2, Ravg) vs. Standard hemodynamic parameters (dP/dtmax, EDV, ESV, ESP) was evaluated on Coefficient of variation (SD/mean) at a heart rate of 160 beats/min (p=<0.005). Left ventricular pressure decay parameters showed higher beat-to-beat variability (e.g., T 4.7%, P<0.005) than standard hemodynamic parameters like dP/dtmax (1.9%) in normal dog hearts.
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