Key result
In stimulated bullfrog skeletal muscle, ATP utilization was 2.5 mM/s at optimal length compared to 1.07 mM/s when stretched, indicating approximately 43% of ATP is used by noncontractile processes.
Population
Bullfrog semitendinosus muscle (n=6)
Comparison
Tetanic stimulation at optimal length for force… vs Tetanic stimulation at increased sarcomere length
Design
Preclinical
Authors
Loading...
Substantial noncontractile ATP use occurs in stimulated skeletal muscle; leaves open relevance to cardiac energetics and requires mammalian validation.
Absolute Event Rate: 2.5% vs 1.07%
During contraction near optimum length, approximately 43% of ATP is used by noncontractile processes, with more ATP derived from glycolysis than from creatine kinase.
Baker et al. (1994) studied this question. Tetanic stimulation at optimal length vs. Tetanic stimulation at increased sarcomere length (stretched) was evaluated on Total ATP utilization (mM/s). In stimulated bullfrog skeletal muscle, ATP utilization was 2.5 mM/s at optimal length compared to 1.07 mM/s when stretched, indicating approximately 43% of ATP is used by noncontractile processes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: