Key result
Isometric tetani at lmax produces significant unexplained energy, indicating sources beyond actin-myosin interaction.
Population
Frog semitendinosus muscle
Comparison
5s isometric tetani at lmax vs 5s isometric tetani at l0
Design
Preclinical
Authors
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Challenges actin-myosin exclusivity for length-dependent isometric energy; leaves open non-cross-bridge mechanisms in mammalian models.
Unexplained energy production during isometric tetani in frog skeletal muscle is dependent on muscle length but cannot be due solely to actin-myosin interaction.
Curtin et al. (1981) studied Frog skeletal muscle. Muscle length lmax (sarcomere length 3.8 micrometers) vs. Muscle length l0 (sarcomere length 2.3 micrometers) was evaluated on Energy balance (ATP splitting, creatine kinase reaction, and heat + work). A significant amount of unexplained energy is produced at lmax where actin-myosin interaction is negligible, though less than at l0, indicating it is not solely due to actin-myosin interaction.
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