Key result
Down-regulation of Prkar1a by up to 70% in transgenic mice led to thyroid follicular hyperplasia, adenomas, adrenocortical hyperplasia, and other mesenchymal tumors.
Why the study?
Does down-regulation of Prkar1a lead to tumorigenesis in endocrine and other tissues in a transgenic mouse model?
Population
Transgenic mice carrying an antisense transgene for Prkar1a exon 2 under the control of a…
Design
Preclinical
Authors
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Prkar1a down-regulation is associated with tumors in mice; leaves open human relevance and should not change practice.
Does down-regulation of Prkar1a lead to tumorigenesis in endocrine and other tissues in a transgenic mouse model?
The establishment of a novel transgenic mouse model confirms the critical role of Prkar1a down-regulation in the tumorigenesis of endocrine and other tissues.
Griffin et al. (2004) studied Endocrine and other tumors. Down-regulation of Prkar1a via antisense transgene (X2AS) was evaluated on Tumor development (thyroid follicular hyperplasia, adenomas, adrenocortical hyperplasia, and other tumors). Down-regulation of Prkar1a by up to 70% in transgenic mice led to thyroid follicular hyperplasia, adenomas, adrenocortical hyperplasia, and other mesenchymal tumors.
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