Key result
A 30-year risk prediction model incorporating measured fitness demonstrated good discrimination for cardiovascular mortality (c-statistic 0.81 in men and 0.86 in women).
Why the study?
Does incorporating measured fitness improve 30-year risk prediction for cardiovascular mortality in individuals without prior cardiovascular disease?
Population
16,533 participants without prior cardiovascular disease from the Cooper Center Longitudinal Study (CCLS)
Design
Cohort
Follow-up
median 28 years
Authors
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May enhance long-term CV mortality stratification when added to traditional factors; extends risk models but leaves open prospective validation and adoption.
Cohort (n=16,533)
Does incorporating measured fitness improve 30-year risk prediction for cardiovascular mortality in individuals without prior cardiovascular disease?
Incorporating measured fitness into traditional risk factor models provides well-calibrated and discriminative 30-year risk prediction for cardiovascular mortality.
Wickramasinghe et al. (2014) conducted a cohort in Without prior cardiovascular disease (n=16,533). Measured fitness vs. Higher fitness levels was evaluated on 30-year risk for cardiovascular mortality. A 30-year risk prediction model incorporating measured fitness demonstrated good discrimination for cardiovascular mortality (c-statistic 0.81 in men and 0.86 in women).
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