Key result
Covalent attachment of Pluronic copolymers to red blood cells predictably modified RBC aggregation and whole blood viscosity depending on the critical micellization temperature.
Covalent attachment of Pluronic copolymers to RBCs provides a novel tool to predictably modulate RBC aggregation and blood viscosity for hemorheology research.
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May enable tunable RBC rheology in preclinical models; leaves open clinical translation for viscosity-related disorders.
Armstrong et al. (2001) studied this question. Covalent attachment of Pluronic copolymers to RBC membrane was evaluated on RBC aggregation and whole blood viscosity. Covalent attachment of Pluronic copolymers to red blood cells predictably modified RBC aggregation and whole blood viscosity depending on the critical micellization temperature.
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