Key result
In guinea-pigs, tocainide caused HV intervals to increase in a strictly rate-dependent fashion, confirming its classification as a class I antiarrhythmic agent with fast onset and offset kinetics.
p-value: p=<0.001
In vivo data confirm tocainide acts as a class I antiarrhythmic agent with fast onset and offset kinetics, causing rate-dependent slowing of intraventricular conduction.
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Confirms tocainide's fast class I kinetics in guinea-pigs; leaves open clinical translation and human efficacy.
Todt et al. (1993) studied this question. Tocainide vs. Baseline was evaluated on HV intervals at different cycle lengths (p=<0.001). In guinea-pigs, tocainide caused HV intervals to increase in a strictly rate-dependent fashion, confirming its classification as a class I antiarrhythmic agent with fast onset and offset kinetics.
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