Key result
Healthy Japanese residents with above-median serum endostatin levels had significantly higher carotid intima-media thickness compared to those with below-median levels (0.71 vs. 0.65 mm).
Why the study?
Is a higher serum endostatin level associated with increased carotid intima-media thickness in healthy Japanese residents?
Cross-Sectional (n=648)
Is a higher serum endostatin level associated with increased carotid intima-media thickness in healthy Japanese residents?
Effect estimate: beta 0.11
Absolute Event Rate: 0.71% vs 0.65%
p-value: p=<0.001
Higher serum endostatin levels are independently associated with increased carotid intima-media thickness, suggesting its utility as a marker for subclinical atherosclerosis.
Endostatin may mark subclinical atherosclerosis; cross-sectional data leave open prognostic value and preclude practice change.
AIM: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. METHODS: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. RESULTS: The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7-93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P＜0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta=0.11, P=0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. CONCLUSIONS: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.
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Kato et al. (2017) conducted a cross-sectional in Subclinical atherosclerosis (n=648). Above median serum endostatin level (≥63.7 ng/mL) vs. Below median serum endostatin level (<63.7 ng/mL) was evaluated on Carotid intima-media thickness (IMT) (beta 0.11, p=<0.001). Healthy Japanese residents with above-median serum endostatin levels had significantly higher carotid intima-media thickness compared to those with below-median levels (0.71 vs. 0.65 mm).
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