Asymptomatic carotid atherosclerosis with >50% stenosis was present in 4.4% of an urban Japanese population (7.9% men, 1.3% women) and significantly associated with cardiovascular risk factors.
Cross-Sectional (n=1,694)
No
What is the prevalence of asymptomatic carotid atherosclerosis and its association with cardiovascular risk factors in an urban Japanese population?
The prevalence of severe asymptomatic carotid atherosclerosis in an urban Japanese population is comparable to developed Western countries and strongly associated with traditional cardiovascular risk factors.
p-value: p=<.05
BACKGROUND AND PURPOSE: Because extracranial carotid atherosclerotic lesions have been considered rare, no reports have been published on the prevalence and distribution of these lesions in a general Japanese population. However, recent changes in lifestyle are thought to have caused an increase in these lesions. The aim of this study was to use high-resolution ultrasonography to examine the prevalence of asymptomatic extracranial carotid artery lesions and its relation to cardiovascular risk factors in an urban Japanese population. METHODS: The subjects were 814 men and 880 women aged 50 to 79 years randomly sampled from the residents of Suita, a city located in the second largest urban area of Japan. Asymptomatic carotid lesions were detected and evaluated by a single physician with high-resolution B-mode ultrasonography. RESULTS: We found significant sex differences in the prevalence of atherosclerotic lesions in the extracranial carotid artery; 4.4% of all the subjects, 7.9% of the men, and 1.3% of the women had atherosclerosis accompanied by stenosis of >50%. A strong association between these lesions and the results of a 75-g oral glucose tolerance test was found in both sexes. Multiple regression analysis of carotid atherosclerosis showed significant relationships with age, systolic blood pressure, fasting blood glucose, pack-years of smoking, total serum cholesterol, and HDL cholesterol in men (P50% stenosis was not low and was almost equal to that reported in developed western countries.
Mannami et al. (Sat,) conducted a cross-sectional in Asymptomatic carotid atherosclerotic lesions (n=1,694). Cardiovascular risk factors was evaluated on Prevalence of atherosclerosis accompanied by stenosis of >50% (p=<.05). Asymptomatic carotid atherosclerosis with >50% stenosis was present in 4.4% of an urban Japanese population (7.9% men, 1.3% women) and significantly associated with cardiovascular risk factors.