Key result
Having three or more cerebrovascular risk factors significantly increased the odds of early carotid atherosclerosis compared to having no risk factors in both men (OR 2.95) and women (OR 3.52).
Why the study?
Does the accumulation of multiple vascular risk factors increase the risk of early carotid atherosclerosis and systemic inflammation in Japanese adults?
Cross-Sectional (n=1,880)
No
Does the accumulation of multiple vascular risk factors increase the risk of early carotid atherosclerosis and systemic inflammation in Japanese adults?
The accumulation of multiple traditional vascular risk factors is strongly associated with early carotid atherosclerosis and elevated hs-CRP levels in Japanese adults.
Multiple risk factors were associated with early carotid atherosclerosis in Japanese adults; leaves open causality, inflammation links, and need for longitudinal data.
OBJECTIVE: The aim of this study was to assess the significance of multiple risk factors for early carotid atherosclerosis in the Japanese population. METHODS: The relation between traditional vascular risk factors and serum high-sensitivity CRP (hs-CRP) or atherosclerotic lesions in the carotid arteries detected by B-mode ultrasonography was evaluated. PATIENTS: The subjects were 1,880 persons (1,240 men and 640 women, mean age 55+/-10 years old) without ischemic stroke, infection or collagen diseases. RESULTS: In the men, the odds ratio (OR) for atherosclerotic lesion was increased at 1.90 (95% CI: 1.05-3.43, P=0.032) in those with one risk factor, 2.42 (1.36-4.32, P=0.002) in those with two, and 2.95 (1.69-5.16, P<0.001) in those with three or more. In the women, the OR was similarly increased 1.93 (95% CI: 1.04-3.56, P=0.035) for one risk factor, 2.31 (1.23-4.33, P=0.009) for two, and 3.52 (1.80-6.87, P<0.001) for three or more. The mean hs-CRP concentration increased significantly with the increasing number of risk factors (men and women, P<0.001) and with the degree of carotid arterial stenosis (men, P=0.011; women, P=0.008). CONCLUSION: Multiple risk factors are more predictive than a single risk factor for early carotid atherosclerosis in the Japanese population.
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Takahashi et al. (2007) conducted a cross-sectional in Early carotid atherosclerosis (n=1,880). Three or more cerebrovascular risk factors vs. No risk factors was evaluated on Atherosclerotic lesions in the carotid arteries (IMT > 1.0 mm) (OR 2.95, 95% CI 1.69-5.16, p=<0.001). Having three or more cerebrovascular risk factors significantly increased the odds of early carotid atherosclerosis compared to having no risk factors in both men (OR 2.95) and women (OR 3.52).
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